M. Eileen Dolan
The University of Chicago, USA
Biography
M Eileen Dolan’s lab is focused on improving the quality of life of cancer patients through the identification of genetic variants associated with risk for severe and persistent toxicities following chemotherapy (i.e. peripheral neuropathy, ototoxicity, tinnitus), particularly in children and young adults whose adverse sequelae could persist throughout their lifetimes. To this end, they perform clinical genome-wide association studies (GWAS) to identify genetic variants associated with toxicity in patients following chemotherapy. In addition, they develop preclinical models to elucidate the biochemical and cellular impact of genes identified in clinical GWAS studies of chemotherapeutic toxicity. More recently, her laboratory has developed an induced pluripotent stem cell-derived neural cell model to evaluate genes contributing to chemotherapeutic-induced neuropathy, a common adverse event of multiple chemotherapeutic agents. Using patient-derived induced pluripotent stem cells, they are developing models that will have broad applicability for gaining insight on druggable targets to treat or prevent this devastating side effect of chemotherapy.
Abstract
Abstract : Role of Pharmacogenomics in identifying cancer survivors at risk for adverse, persistent toxicities