Olorunseun O Ogunwobi
Hunter College, City University of New York, USA
Title: MicroRNA-1207-3p in metastatic castrate-resistant prostate cancer
Biography
Biography: Olorunseun O Ogunwobi
Abstract
Prostate cancer (PCa) is the most commonly diagnosed cancer in males in the western world. It is frequently lethal when cancer becomes resistant to androgen deprivation therapy. At this stage, it is clinically described as castration-resistant prostate cancer (CRPC). The molecular mechanisms underpinning progression to this deadly stage are unclear; however, dysregulation of the androgen receptor (AR) has been strongly implicated. Aside from the AR gene locus, one of the bestestablished susceptibility loci for PCa is the 8q24 human chromosomal region. The 8q24 region is a gene “desert” that contains the non-protein coding gene locus PVT1, which encodes six annotated microRNAs (miRNAs). The role of these six miRNAs in PCa is unclear. My talk will focus on the role in PCa of one of the six PVT1- encoded miRNAs, miR-1207-3p.